Micromedex med Martindale via https://www.helsebiblioteket.no/

Maximum reported stability periods:

In D5W- 36 days refrigerated and at room temperature.

In NS- 3 months refrigerated and at room temperature.

Packaged in Syringes:

Several studies have evaluated the stability of midazolam hydrochloride undiluted and diluted in sodium chloride 0.9% packaged in various brands of polypropylene syringes. All of the studies have reported the drug to be stable for periods ranging from 10 days to 36 days at room temperature.

Interaction with Plastics

Midazolam hydrochloride at pH values usually occurring in normal admixture solutions has not been found to undergo substantial sorption to polyvinyl chloride (PVC), polyolefin plastics such as polyethylene, polypropylene (in syringes) or other syringe components, or glass containers. Midazolam losses that occurred have usually been less than 6%, and most often no loss was found.

LightEffects  

Intact containers of midazolam hydrochloride should be protected from exposure to light during long-term storage. Andersin and Tammilehto reported exposure of Roche midazolam vials to direct sunlight caused a yellow discoloration to form in 1 month and about 8% loss of midazolam in 4 months.

For shorter-term exposure to light that occurs during handling, preparation, and administration, no special light protection is required. McMullin et al. reported that Roche midazolam 1 mg/mL in sodium chloride 0.9% with 1% benzyl alcohol was stable for 10 days at a room temperature of 23 °C both exposed to fluorescent light and shielded from exposure to light. Stability-indicating HPLC analysis found no change in the midazolam concentrations and no increase in photodegradation products.

Stabilis.org

Monographie - Midazolam hydrochloride - Stabilis 4.0

Stabil ved konsentrasjon 0,5 mg/ml fortynnet i NaCl 9 mg/ml eller glukose 50 mg/ml i polyolefin infusjonsposer oppbevart i kjøleskap (4˚C) eller romtemperatur (22-24˚C) i 30 dager.

Stabilis.org

Monographie - Midazolam hydrochloride - Stabilis 4.0

Stabilis.org

Monographie - Midazolam hydrochloride - Stabilis 4.0

Stabil ved lagring i hetteglass ufortynnet (5 mg/ml), samt i hetteglass og plastemballasje fortynnet til 0,5 mg/ml med glukose 50 mg/ml ved 23˚C, 8˚C og -20˚C i 14 dager.

Stabilis.org

Monographie - Midazolam hydrochloride - Stabilis 4.0

Stabil ved lagring i polypropylensprøyter ved 24-26˚C ufortynnet (5 mg/ml) og lysbeskyttet i 36 dager. Stabil ved lagring i hetteglass ved 5˚C, 25˚C og 40˚C fortynnet (0,5 mg/ml) i både glukose og natriumklorid i 36 dager. NB! Det er brukt Versed 5 mg/ml, som er et midazolampreparat konservert med benzylalkohol.

Stabilis.org

Monographie - Midazolam hydrochloride - Stabilis 4.0